Intrinsic activation of cardiosphere-derived cells enhances myocardial repair
نویسندگان
چکیده
منابع مشابه
Magnetic targeting enhances engraftment and functional benefit of iron-labeled cardiosphere-derived cells in myocardial infarction.
RATIONALE The success of cardiac stem cell therapies is limited by low cell retention, due at least in part to washout via coronary veins. OBJECTIVE We sought to counter the efflux of transplanted cells by rendering them magnetically responsive and imposing an external magnetic field on the heart during and immediately after injection. METHODS AND RESULTS Cardiosphere-derived cells (CDCs) w...
متن کاملHuman cardiosphere-derived cells from advanced heart failure patients exhibit augmented functional potency in myocardial repair.
OBJECTIVES This study sought to compare the regenerative potency of cells derived from healthy and diseased human hearts. BACKGROUND Results from pre-clinical studies and the CADUCEUS (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction) trial support the notion that cardiosphere-derived cells (CDCs) from normal and recently infarcted hearts are capable of regenerati...
متن کاملPretreatment of Cardiac Stem Cells With Exosomes Derived From Mesenchymal Stem Cells Enhances Myocardial Repair.
BACKGROUND Exosomes derived from mesenchymal stem cells (MSCs) were proved to boost cell proliferation and angiogenic potency. We explored whether cardiac stem cells (CSCs) preconditioned with MSC exosomes could survive and function better in a myocardial infarction model. METHODS AND RESULTS DiI-labeled exosomes were internalized with CSCs. They stimulated proliferation, migration, and angio...
متن کاملΒ-blockers treatment of cardiac surgery patients enhances isolation and improves phenotype of cardiosphere-derived cells
Β-blockers (BB) are a primary treatment for chronic heart disease (CHD), resulting in prognostic and symptomatic benefits. Cardiac cell therapy represents a promising regenerative treatment and, for autologous cell therapy, the patients clinical history may correlate with the biology of resident progenitors and the quality of the final cell product. This study aimed at uncovering correlations b...
متن کاملCardiosphere-derived cells for heart regeneration.
www.thelancet.com Vol 379 June 30, 2012 2425 2 Lemos B, Araripe LO, Hartl DL. Polymorphic Y chromosomes harbor cryptic variation with manifold functional consequences. Science 2008; 319: 91–93. 3 Lemos B, Branco AT, Hartl DL. Epigenetic eff ects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual confl ict. Proc Natl Acad Sci USA 2010; 107: 15826–31. 4 Spach ...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 2020
ISSN: 0022-5223
DOI: 10.1016/j.jtcvs.2020.05.040